The 2020 season was the Carolina Panthers' 26th in the National Football League (NFL) and their first under head coach Matt Rhule.

The offseason saw several notable departures; quarterback Cam Newton was released after the Panthers were unable to find a team willing to trade for him, while linebacker Luke Kuechly announced his retirement on January 14, 2020.

On December 21, 2020 the Panthers parted ways with general manager Marty Hurney after a total of 19 seasons with the organization.

Carolina traveled down south to Tampa Bay to face their new quarterback, Tom Brady.

The Panthers started the game off with scoring two touchdowns by Mike Davis and Teddy Bridgewater in the first quarter.

In the second Arizona's Patrick Peterson intercepted a pass intended for Ian Thomas.

Kyler Murray threw a three-yard pass to Jordan Thomas resulting in a Cardinals touchdown.

Joey Slye kicks a field goal for Carolina, and Chase Edmonds scores a touchdown for Arizona in the fourth.

Ahead of this matchup, the Panthers announced that they would be deploying robotic technology to disinfect areas around their stadium and locker room as an effort to keep fans and players safe from COVID-19.

It was another close one for the Panthers but they ended up losing to Saints 24–27 after Joey Slye missed a tying field goal, and fall to 3–4.

This was quarterback Teddy Bridgewater's first return to New Orleans since leaving the team via free agency during the offseason.