Receiving the opening kickoff (from former Rams kicker Greg Zuerlein), Los Angeles drove 75 yards in seven plays, with Malcolm Brown scoring the new stadium's first touchdown on a 1-yard run.

The Rams reclaimed the lead as Malcolm Brown (who finished with a team-high 18 rushes for 79 yards) scored his second touchdown of the game on a 2-yard run midway through the third quarter to put Los Angeles ahead 20–14.

Linebacker Micah Kiser had a breakout performance that earned him NFC Defensive Player of the Week honors and tight end Tyler Higbee caught three touchdowns as the Rams broke a six-game losing streak to the Eagles (dating back to 2004) and gave head coach Sean McVay his first victory over Philadelphia after two prior defeats.

After the Eagles bounced back with a pair of touchdowns in the second quarter, the Rams extended their lead as kicker Samuel Sloman added a 30-yard field goal in the third period.

A questionable interception of Allen on the next drive by Rams safety John Johnson, who was credited with the pick after reaching for the ball as tight end Tyler Kroft caught it,[18] helped to set up a 25-yard touchdown pass from Goff to wide receiver Robert Woods, who was playing for the first time against the team that originally drafted him.

Woods, who finished with five receptions for 74 yards, had a 31-yard catch that set up Goff's second touchdown pass of the day, this time to wide receiver Cooper Kupp with 10:40 remaining in the game.

Tight end Gerald Everett took in a handoff from quarterback Jared Goff for a 2-yard run to score the first rushing touchdown of his career, capping off L.A.'s efficient 12-play, 65-yard opening drive.

Kupp turned upfield and outraced Giants defenders to the end zone to complete the 55-yard touchdown pass play and extend the Rams' lead to 17–9 after Sloman's successful PAT.

With just under a minute remaining, Jones's pass attempt to wide receiver Damion Ratley was intercepted by Rams cornerback Darious Williams at the Los Angeles 7-yard-line to preserve the victory.

Running back Darrell Henderson ran for one touchdown and caught another, while rookie Cam Akers led Los Angeles with 61 yards on nine carries in his first action after suffering a rib injury in Week 2.

49ers quarterback Jimmy Garoppolo threw three touchdown passes in the first half, improving his lifetime record against Los Angeles to 4-0 as San Francisco staked out a 21-6 halftime lead.

Sloman converted a 42-yard field goal in the third period, and Josh Reynolds caught a 40-yard TD pass from Goff late in the fourth quarter as the Rams fell to 4-2 on the season.

A dominant performance by defense and special teams lifted the Rams over the visiting Bears on Monday Night Football in their third straight meeting on national TV in as many years.

Early in the first quarter, defensive tackle Aaron Donald sacked Miami rookie quarterback Tua Tagovailoa, forcing a fumble that was recovered by linebacker Leonard Floyd at the Dolphin 15.

But two plays later, Goff was sacked by Dolphins defensive end Emmanuel Ogbah, who forced a fumble that was picked up by linebacker Andrew Van Ginkel, who returned it 78 yards for a touchdown.

Cornerback Darious Williams snagged two interceptions and the Rams defense sacked Seahawks quarterback Russell Wilson six times to lead Los Angeles to victory at home in a key NFC West showdown.

Kai Forbath finished L.A.'s opening drive with a 23-yard field goal, while Darrell Henderson and Malcolm Brown both scored on touchdown runs to give the Rams a 17-7 lead in the second quarter.

Brown added another touchdown run in the third period, while the Seahawks were limited to three field goals from kicker Jason Myers (including a Seahawks-record 61-yarder at the end of the second quarter.

Williams stopped two scoring drives with interceptions and also had three pass deflections on the day, while fellow corner Jalen Ramsey had two tackles and was successful in limiting Seattle's leading receiver DK Metcalf to just two receptions for 28 yards.

In a high-stakes battle on Monday Night Football, the Rams took down the favored Buccaneers for the fourth straight time at Raymond James Stadium dating back to 2012.

Leading 17-14 at halftime, the Rams never trailed in the second half as Goff hit rookie running back Cam Akers for a TD on a swing pass out of the backfield in the third quarter, and Gay added a 40-yard field goal with 2:40 remaining in the game.

Cornerback Troy Hill capped off L.A.'s stellar defensive effort with a 35-yard touchdown interception return of a pass by Arizona quarterback Kyler Murray, who was held to just 15 rushing yards on the day.

The victory, combined with the Seattle Seahawks' upset loss to the New York Giants the same day, put the Rams back in first place in the NFC West with four weeks remaining in the NFL regular season.

Facing the Patriots for the first time since their 13-3 loss in Super Bowl LIII, the host Rams dominated from the opening drive, going 75 yards in six plays to finish with quarterback Jared Goff scoring on a 1-yard run.

Wide receiver Cooper Kupp caught a 2-yard TD pass from Goff for the only score of the second half, as L.A. assured itself of a winning record at its new home by improving to 5-1 at SoFi Stadium.

New York, entering the game with an 0–13 record and as a 17-point underdog, drove 76 yards in 13 plays on their opening offensive drive, capping it with an 18-yard touchdown pass from former USC quarterback Sam Darnold to Ty Johnson.

But the Rams hurt themselves badly on their next two drives as quarterback Jared Goff threw an errant pass that was intercepted by Seattle cornerback Quandre Diggs at the Seahawks' 10-yard line.

The Rams shut down the visiting Cardinals to secure their third playoff appearance in four seasons as head coach Sean McVay maintained his unbeaten record against Arizona (8-0).

After an exchange of punts, Wolford led the Rams on a 16-play, 69-yard drive that reached the Arizona 1, but successive false start penalties moved the ball back and Los Angeles settled for a 28-yard field goal by Matt Gay.

Starting for the second straight week, quarterback John Wolford completed passes of 15 and 13 yards to wide receiver Cooper Kupp, but was then knocked out of the game after colliding with Seattle safety Jamal Adams on a scramble down to the Seahawks 18.