[1] On November 29, 2020, the Jaguars fired general manager David Caldwell following a 1–10 start to the season.

[2] The Jaguars had the worst record in the 2020 season, and thereby earned the first overall draft pick for the first time in franchise history after a Week 16 loss to the Chicago Bears coupled with a win by the New York Jets.

[3] Following their Week 17 loss to the Indianapolis Colts, the Jaguars became the fourth team in NFL history (and the second since the 16-game expansion) to win their season opener but lose their remaining games; the only other teams that accomplished this were the 1936 Philadelphia Eagles, the 1969 Pittsburgh Steelers, and the 2001 Carolina Panthers.

On January 4, 2021, the Jaguars fired head coach Doug Marrone, who finished his tenure in Jacksonville with a 25–44 (.362) record.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Jaguars' preseason schedule was announced on May 7, but was later cancelled due to the COVID-19 pandemic.