It was also their third season under head coach Frank Reich and fourth under the leadership of general manager Chris Ballard.

Rivers' retirement left Russell Wilson of the Seattle Seahawks as the new longest active leader for consecutive starts by a quarterback.

Front office Head coaches Offensive coaches Special teams coaches Strength and conditioning Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The Colts' preseason schedule was announced on May 7, but was later cancelled due to the COVID-19 pandemic.

The Colts failed to win in Week 1 for the seventh consecutive season, dating back to 2014.

Sam Darnold threw three interceptions, two of which were returned for touchdowns by Colts defensive backs, and was sacked in the end zone for a safety.

After trailing 0–21 in the second quarter, the Colts outscored the Bengals 31–6 to improve to 4–2 entering their bye week.

As one of five AFC teams with a 10–5 record entering Week 17, the Colts were on the outside of the playoff picture until the Miami Dolphins fell to the Buffalo Bills earlier in the afternoon.

With the win and the Houston Texans' loss to the Tennessee Titans, the Colts finished the season with an 11–5 record and were eliminated from contention for the division title, but clinched the seventh and final wild card slot in the expanded NFL playoffs.

In what would become quarterback Philip Rivers' last game in the NFL,[5] the Colts fell to the Bills by a final score of 27–24 despite coming back from a 24–10 fourth-quarter deficit.