The 2020 season was the San Francisco 49ers' 71st in the National Football League (NFL), their 75th overall, and their fourth under the head coach/general manager tandem of Kyle Shanahan and John Lynch.

Running backs (RB) Wide receivers (WR) Tight ends (TE) Defensive linemen (DL) Defensive backs (DB) Special teams Reserve The 49ers' preseason schedule was announced on May 7, but was later canceled due to the COVID-19 pandemic.

Although the 49ers won easily over the struggling Jets, they suffered devastating injuries on both sides of the ball to Jimmy Garoppolo, Raheem Mostert, Tevin Coleman, Nick Bosa, and Solomon Thomas.

Nick Mullens struggled mightily in the game with two interceptions, one of which was returned by Alex Singleton for a touchdown, and was benched afterwards for C. J. Beathard.

Jimmy Garoppolo returned from injury but struggled mightily with 2 interceptions, leading to him being benched at halftime for C. J. Beathard.

Jimmy Garoppolo threw 3 touchdowns and 268 yards and the 49ers defense was able to hold a red-hot Rams offense in check.

The 49ers returned from their bye week with some much-needed reinforcement returning from injury: on offense, Raheem Mostert scored a touchdown and 43 yards rushing and Deebo Samuel had 133 receiving yards; on defense, Richard Sherman contributed by grabbing his first interception of the season.

The two teams had four combined turnovers in the first quarter, and the only points scored in the first half came on a Raheem Mostert touchdown and a Matt Gay field goal.

Early in the third quarter, the 49ers padded their lead to fourteen points with Javon Kinlaw's pick six and a Robbie Gould field goal.

However, the momentum changed quickly as Aaron Donald forced a fumble on Raheem Mostert and it was returned for a touchdown by Troy Hill.

Due to the COVID-19 pandemic in Santa Clara County halting all contact sports the 49ers decided to use State Farm Stadium for 2 games.

San Francisco also allowed Cowboys wide receiver CeeDee Lamb to return a kickoff for a touchdown, which sealed the 49ers' loss.