The Astros finished the regular season 29–31, becoming the second American League team to reach the playoffs with a losing record, the first being the 1981 Kansas City Royals.

After the season, pitcher Cristian Javier was named a finalist for the 2020 AL Rookie of the Year Award, finishing third in voting.

On March 12, 2020, MLB announced that because of the ongoing COVID-19 pandemic, the start of the regular season would be delayed by at least two weeks in addition to the remainder of spring training being cancelled.

[2] Four days later, it was announced that the start of the season would be pushed back indefinitely due to the recommendation made by the CDC to restrict events of more than fifty people for eight weeks.

Astros players or team staffers watching the live camera feed behind the dugout used various audio cues to signal to the batter what type of pitch was coming next.

MLB found no evidence of illicit sign stealing in the 2019 season, in which the Astros advanced to the World Series but lost.

Carlos Beltrán was the only Astros player from 2017 who was specifically named in the report; he had been hired to manage the New York Mets in November 2019 but parted ways with the team after the results of MLB's investigation were announced.

Meanwhile, George Springer tied the game with an RBI single, and the Astros scored 3 runs in the 9th off Sergio Romo & Caleb Thielbar.

Due to the continuing COVID-19 pandemic, all games of the series were played at Dodger Stadium in Los Angeles.

A's DH Khris Davis got the scoring started with a two-run home run in the second inning, followed by a Sean Murphy solo shot in the third.

The Astros took the lead in the sixth, when Josh Reddick reached on a fielding error with two outs and Martín Maldonado singled.

The Astros then broke it open in the ninth inning with a Correa RBI single and a Yuli Gurriel sacrifice fly.

Left-handed pitcher Framber Valdez started game two of the series against A's left hander Sean Manaea.

Martín Maldonado and Springer hit back-to-back home runs in the fifth inning to push the Astro's lead to 5–2.

Ryan Pressly picked up the save for the Astros as they moved the A's to the edge of elimination with a 2–0 game lead in the series.

A's second baseman Tommy La Stella got the scoring started with a solo home run in the first inning.

The Astros responded with a solo home run from Jose Altuve and a Correa RBI groundout to take the lead in the bottom of the first.

A's closer Liam Hendriks pitched three scoreless innings to save the A's season and send the series to a Game 4.

In the bottom of the fifth, Brantley hit his second home run of the game and Correa added an RBI single to make it 7–4.

The A's attempted to mount a comeback in the ninth when Marcus Semien drove in a run on a single and Tommy La Stella singled in Semien before Astros closer Ryan Pressly shut the door in the ninth to send the Astros to the ALCS.

Due to the continuing COVID-19 pandemic, all games of the best-of-seven series were played at Petco Park in San Diego, California.

A hit batter drove in another run and a double with the bases loaded by Hunter Renfroe gave the Rays a 5–1 lead.

Ryan Pressly was able to get the final out and move the series to Game 5 with the Astros trailing three-games-to-one.

With only six outs remaining in the game, the Rays tied it in the top of the eighth on a Ji-man Choi solo home run.

As of mid-April 2020, Astro teammates Carlos Correa and Martin Maldonado, along with fellow Major Leaguers such as Francisco Lindor and Eddie Rosario, as well as musical stars, have already shipped 26 pallets of medical supplies to the U.S. territory of Puerto Rico.