The 2021–22 FC Zbrojovka Brno season is the club's fourth season in the Fortuna národní liga.

The team is competing in Fortuna národní liga and the Czech Cup.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.

Players may hold more than one non-FIFA nationality.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.