On 18 June, head coach Pablo Laso extended his contract until the end of the 2022–2023 season.

[13] Note: The game, originally scheduled for 2 January 2022, was postponed due to a COVID-19 outbreak in Barça's squad.

[14] Note: The game, originally scheduled for 23 January 2022, was postponed due to the massive rescheduling of the 2021–22 ACB season caused by the COVID-19 pandemic.

[16] Note: The match, originally scheduled for 6 January 2022, was postponed due to a COVID-19 outbreak within UNICS' squad.

[16] Note: The match, originally scheduled for 29 December 2021, was postponed due to a COVID-19 outbreak within Real Madrid's squad.

[17] Note: The match, originally scheduled for 11 January 2022, was postponed due to a COVID-19 outbreak within Zvezda's squad.