The season began on 24 July 2021 and concluded on 14 May 2022.

[2][3] A promotion play-off competition was held at the end of the season, involving the 3rd, 4th and 5th-placed teams in 2021–22 Ligue 2, and the 18th-placed team in 2021–22 Ligue 1.

[26] Round 1 Round 2 Promotion Play-off Final1st leg 2nd leg 2–2 on aggregate, Auxerre won 5–4 on penalties and were promoted to 2022–23 Ligue 1; Saint-Étienne were relegated to 2022–23 Ligue 2.

A relegation play-off was held at the end of the season between the 18th-placed team of the 2021–22 Ligue 2 and the 3rd-placed team of the 2021–22 Championnat National.

[1] First leg Second leg Quevilly-Rouen won 5–1 on aggregate and therefore both clubs remained in their respective leagues.