The 2021 Almaty Challenger II was a professional tennis tournament played on clay courts.

It was the sixth edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Almaty, Kazakhstan between 14 and 20 June 2021.

The following players received entry into the singles main draw as wildcards: The following player received entry into the singles main draw as a special exempt: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: