The 2021 Ceratizit Challenge by La Vuelta was a women's road cycling stage race that was held in the region of Galicia in northwestern Spain from 2 to 5 September 2021.

It was the seventh edition of the Ceratizit Challenge by La Vuelta and was the fifteenth event on the 2021 UCI Women's World Tour calendar.

All nine UCI Women's WorldTeams and fifteen UCI Women's Continental Teams made up the twenty-four teams that participated in the race.

[3] Several teams did not enter a full squad of six riders: Alé BTC Ljubljana, Eneicat–RBH Global–Martín Villa, FDJ Nouvelle-Aquitaine Futuroscope, InstaFund Racing, and Team BikeExchange each entered five riders, while Ceratizit–WNT Pro Cycling only entered four.

[2] UCI Women's WorldTeams UCI Women's Continental Teams The 2021 edition increased the number of stages to 4, with the race finishing in Santiago de Compostela.