The 2021 Trofeo Alfredo Binda-Comune di Cittiglio was the 45th running of the Trofeo Alfredo Binda, a women's cycling race in Italy.

It was the second event of the 2021 UCI Women's World Tour season and was held on 21 March 2021.

The race started in Cocquio-Trevisago and finished in Cittiglio, on the outskirts of Lago Maggiore in Northwest Italy.

[1] The event was cancelled in 2020 due to the COVID-19 pandemic.

[3] UCI Women's WorldTeams UCI Women's Continental Teams This cycling race article related to Italian cycling is a stub.