The 2021 Vuelta a Burgos Feminas was a road cycling stage race that took place in the province of Burgos in northern Spain between 20 and 23 May 2021.

It was the sixth edition of the Vuelta a Burgos Feminas, and the first as a newly promoted event to the 2021 UCI Women's World Tour.

[1][2] Eight of the nine UCI Women's WorldTeams and twelve UCI Women's Continental Teams made up the twenty teams that participated the race.

[3][4][5] Six teams did not field the maximum allowed of six riders; these teams were Bizkaia–Durango, Cogeas–Mettler–Look, Eneicat–RBH Global–Martín Villa, InstaFund Racing, Liv Racing, and Rally Cycling, and each fielded five riders.

108 riders started the race, of which 92 finished.