The 2021 Copa Libertadores qualifying stages were played from 23 February to 15 April 2021.
[3] The draw for the qualifying stages was held on 5 February 2021, 12:00 PYST (UTC−3), at the CONMEBOL Convention Centre in Luque, Paraguay.
Teams from the same association could not be drawn into the same tie, excluding the three winners of the first stage, which were seeded in Pot 2 and whose identity was not known at the time of the draw, and could be drawn into the same tie with another team from the same association.
As their identity was not known at the time of the draw, they could be drawn into the same tie with another team from the same association.
If still tied, extra time will not be played, and a penalty shoot-out will be used to determine the winner (Regulations Article 2.4.3).
Independiente del Valle won 6–3 on aggregate and advanced to the third stage (Match G2).