[5][6] Tied 2–2 on aggregate, Peñarol won on away goals and advanced to the quarter-finals (Match S1).
Red Bull Bragantino won 3–1 on aggregate and advanced to the quarter-finals (Match S2).
Tied 2–2 on aggregate, LDU Quito won on away goals and advanced to the quarter-finals (Match S4).
Tied 4–4 on aggregate, Libertad won on away goals and advanced to the quarter-finals (Match S3).
Red Bull Bragantino won 5–3 on aggregate and advanced to the semi-finals (Match F2).