The 2021 Supercopa Paraguay was the first edition of the Supercopa Paraguay, Paraguay's football super cup.

It was held on 12 December 2021 between the 2021 Primera División best-ranked champions in the aggregate table Cerro Porteño and the 2021 Copa Paraguay champions Olimpia, as the match that closed the 2021 season of Paraguayan football.

[1] Olimpia were the winners, defeating Cerro Porteño by a 3–1 score.

[2] The Supercopa Paraguay is contested by two teams: the champions of the Copa Paraguay and the Primera División (Apertura or Clausura) champions with the best record in the aggregate table of the season.

[3][4] Assistant referees:[7] Eduardo Cardozo Milciades Saldívar Fourth official: Carlos Benítez Video assistant referee: Mario Díaz de Vivar Assistant video assistant referee: Eduardo Britos Support referee: Fernando López Match rules[4]