The 2021 Coppa Sabatini (also known as the Gran Premio città di Peccioli[2]) was the 69th edition of the Coppa Sabatini road cycling one day race, which was held on 16 September 2021 as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries calendars.

The race concluded with three laps of a 12.29-kilometre (7.64 mi) circuit, which finished atop the Via Mazzini hill in Peccioli.

Neilson Powless (EF Education–Nippo) was the first to try a solo attack, but he was brought back with under 3 kilometres (1.9 mi) to go.

In the final kilometre, Gianni Moscon (Ineos Grenadiers) tried to accelerate away but was quickly closed down, before Powless's teammate Michael Valgren, winner of the Giro della Toscana the day before, made what would be the winning acceleration.

Only Sonny Colbrelli (Team Bahrain Victorious), the recently crowned European road race champion, was able to follow Valgren.