The 2021 Tour de Luxembourg was the 81st edition of the Tour de Luxembourg road cycling stage race.

It was held from 14 and 18 September, as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries.

[1][2] Eight UCI WorldTeams, twelve UCI ProTeams, and one UCI Continental team made up the twenty-one teams that participated in the race.

Each team entered a squad of six riders.

[3] After a late non-starter from Uno-X Pro Cycling Team, a total of 125 riders started the race; 103 riders finished.