The 2021 Grand Prix de Fourmies was the 88th edition of the Grand Prix de Fourmies, a one-day road cycling race in and around Fourmies in northern France.

[2] This edition was the race's first in the UCI ProSeries; the 2020 edition was expected to feature in the inaugural UCI ProSeries but was cancelled due to the COVID-19 pandemic.

[3] It was also the ninth event of the 2021 French Road Cycling Cup.

[4] All but four teams fielded a full squad of seven riders; B&B Hotels p/b KTM, Bora–Hansgrohe, Sport Vlaanderen–Baloise, and Trek–Segafredo each entered six riders.

In total, 150 riders started the race, of which 134 finished.