The 2021 Giro dell'Emilia was the 104th edition of the Giro dell'Emilia road cycling one day race in the titular region of central Italy.

[2] The race's hilly route covered 195.3 kilometres (121.4 mi) in and around Bologna, starting from Casalecchio di Reno and finishing at the Sanctuary of the Madonna of San Luca.

The first 150 kilometres (93 mi) of the race consisted of a large circuit around Bologna and featured two sprint points in Zola Predosa and Valsamoggia, followed by three climbs (Ca' Bortolani, Passo Brasa, and Medelana) and a third sprint point at the Parco dei Ciliegi.

Each lap began with a short descent from the sanctuary and a short climb to Montalbano, before a descent into Bologna and the climb back up to San Luca.

In total, 162 riders started the race, of which only 55 finished.