The 2021 Grand Prix de Wallonie was the 61st edition of the Grand Prix de Wallonie road cycling one day race, which was held on 14 September 2021 as part of the 2021 UCI Europe Tour and the 2021 UCI ProSeries calendars.

[3] This edition was the race's first in the UCI ProSeries; the 2020 edition was expected to feature in the inaugural UCI ProSeries but was cancelled due to the COVID-19 pandemic.

[5] After travelling west from the start, riders reached the outskirts of Namur and entered a local circuit after 138.5 kilometres (86.1 mi).

The race then conclude with a 2.7-kilometre (1.7 mi) climb up to the citadel.

[1][4] After a late attack from Matis Louvel (Arkéa–Samsic) in the final kilometre was brought back, Christophe Laporte (Cofidis) won the uphill sprint from a reduced bunch ahead of Louvel's teammate Warren Barguil, while Tosh Van der Sande (Lotto–Soudal) finished third.