The 2021 Internationaux de Tennis de Vendée was a professional tennis tournament played on hard courts.

It was the eighth edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Mouilleron-le-Captif, France between 4 and 10 October 2021.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: