The 2021 Internazionali di Tennis del Friuli Venezia Giulia was a professional tennis tournament played on clay courts.

It was the 18th edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Cordenons, Italy between 2 and 8 August 2021.

The following players received wildcards into the singles main draw: The following player received entry into the singles main draw as a special exempt: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: