The 2021 LTP Women's Open was a professional tennis tournament played on outdoor green clay courts.

It was the 1st edition of the tournament and part of the 2021 WTA 125K series, offering a total of $115,000 in prize money.

It took place in Charleston, South Carolina, United States from 26 July to 1 August 2021.

[1] The following players received a wildcard into the singles main draw: The following players received entry using protected rankings: The following pair received a wildcard into the doubles main draw: