The 2021 Open de Limoges was a professional tennis tournament played on indoor hard courts.

It was the 14th edition of the tournament and part of the 2021 WTA 125 tournaments series, offering a total of $115,000 in prize money.

It took place at the Palais des Sports de Beaublanc in Limoges, France, from 13 to 19 December 2021.

[1] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: