The 2021 WTA Argentina Open was a professional tennis tournament played on outdoor clay courts.

It was the first edition of the tournament since 1987 and first as part of the 2021 WTA 125 tournaments.

It took place at the Buenos Aires Lawn Tennis Club in Buenos Aires, Argentina[1] between 1 and 7 November 2021.

[2] The following players received wildcards into the singles main draw: The following players received entry from the qualifying draw: The following pairs received a wildcard into the doubles main draw: