The 2021 Dow Tennis Classic was a professional tennis tournament played on indoor hard courts.

It was the twenty-seventh edition of the tournament which was part of the 2021 WTA 125 tournaments.

It took place at the Greater Midland Tennis Center in Midland, Michigan, United States between 1 and 7 November 2021.

[1] The following players received wildcards into the singles main draw: The following players received entry using protected rankings: The following players received entry from the qualifying draw: