The 2021 Open Angers Arena Loire was a professional tennis tournament played on indoor hard courts.

It was the 1st edition of the tournament and part of the 2021 WTA 125 tournaments season, offering a total of $115,000 in prize money.

It took place in Angers, France from 6 to 12 December 2021.

[1] The following players received a wildcard into the singles main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: