The 2021 Open de Tenis Ciudad de Pozoblanco was a professional tennis tournament played on hard courts.

It was the 15th edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Pozoblanco, Spain between 19 and 25 July 2021.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: