The 2021 Open du Pays d'Aix was a professional tennis tournament played on clay courts.

It was the eighth edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Aix-en-Provence, France between 14 and 20 June 2021.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as alternates: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: