The 2021 Potchefstroom Open II was a professional tennis tournament played on hard courts.

It was the third edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Potchefstroom, South Africa between 15 and 21 February 2021.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw using protected rankings: The following player received entry into the singles main draw as an alternate: The following players received entry from the qualifying draw: