The 2021 Salinas Challenger II was a professional tennis tournament played on green hard courts.

It was the 21st edition of the tournament which was part of the 2021 ATP Challenger Tour.

It took place in Salinas, Ecuador between 26 April and 2 May 2021.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw as special exempts: The following players received entry from the qualifying draw: