He was challenged by construction manager John Sutherland[9] in the Republican primary after Sutherland sued to stop a 2-cent gas tax extension from being pushed through by the Lauderdale County Agricultural Authority, headed by Tim Melson, in order to build an event center just outside the city of Florence, Alabama.

Former state senator Bill Holtzclaw challenged Butler in the primary for his old seat, citing a "lack of communication" in the district during the current term.

[11] PROJECTXYZ founder and former Huntsville Chamber of Commerce Chair Kim Caudle Lewis[21] contested the district in the general election.

Retired electrical engineer Rick Chandler[28] was nominated by the Libertarian Party and challenged Orr in the general election.

United States Navy veteran Kyle Richard-Garrison[35] was nominated by the Libertarian Party and challenged Stutts in the general election.

PACs Organizations Unions First term incumbent Republican senator Sam Givhan had represented the 7th District since November 2018.

[5] Municipal court judge and city attorney Lance Bell[41] along with federal prison chaplain Michael Wright[42] ran in the primary to replace McClendon.

[6] Lawyer Wendy Ghee Draper,[49] real estate firm owner Keith Kelley[50] and Weaver mayor Wayne Willis[51] all ran in the primary to replace Marsh.

[54] Certified public accountant Danny McCullars[55] was nominated by the Democratic Party and contested the district in the general election.

Organizations PACs Unions First term incumbent Republican senator Randy Price had represented the 13th District since November 2018.

Organizations PACs Unions Third term incumbent Republican Senateor Shay Shelnutt had represented the 17th District since November 2018.

Organizations PACs Unions Eighth term incumbent Democratic senator Rodger Smitherman ran unopposed; he had represented the 18th District since February 1994.

Organizations PACs Unions Third term incumbent Republican senator Gerald Allen had represented the 21st District since November 2010.

Retired United States Army chaplain Stephen Sexton[73] challenged Albritton in the primary, receiving one third of the vote.

Retired Alabama Department of Public Health statistician and Holt native Louie Albert Woolbright[77] was nominated by the Libertarian Party and contested the district in the general election.

Organizations PACs Unions Three term incumbent Republican senator Tom Whatley was controversially defeated in the primary by Auburn city councilman Jay Hovey by a single vote.

[11] Shortly after, a New York Times editorial emerged telling a story of how a creative writing professor at Auburn University had convinced a substantial amount of avowed Democrats to vote in the Republican primary for Hovey due to Whatley's "abhorrent" record on legislation regarding abortion.

[needs update] United States Army Human Resources Officer Sherri Reese[81] was nominated by the Democratic Party and challenged Hovey in the general election.

Organizations PACs Sixth term incumbent Republican senator Jimmy Holley had represented the 31st District since November 1998.

[7] Coffee County Commissioner Josh Carnley, aircraft mechanic "Stormin'" Norman Horton, and State Representative Mike Jones all ran in the primary to replace Holley.

Retired United States Navy CO and commercial real estate broker Pete Riehm[87] was nominated by the Republican Party and contested the district in the general election.

The Libertarian Party nominated systems analyst Clifton Hudson,[88] who challenged Sessions in the general election.