The 2022 Christus Health Pro Challenge was a professional tennis tournament played on outdoor hard courts.

It was the sixth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Tyler, Texas, United States between 24 and 30 October 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry from the qualifying draw: