Belinda Bencic defeated Ons Jabeur in the final, 6–1, 5–7, 6–4, to win the singles tennis title at the 2022 Charleston Open.

Her victory made her the first Swiss player to win the title since Martina Hingis in 1999 and earned her the distinction of holding titles across all three major surfaces.

[1][2] Veronika Kudermetova was the defending champion,[3] but she withdrew before the tournament began.

The top eight seeds received a bye into the second round.