The 2022 Ladies Open Lausanne was a women's tennis tournament played on outdoor clay courts.

It was the 29th edition of the Ladies Open Lausanne, and part of the 250 category of the 2022 WTA Tour.

It took place at Tennis Club Stade-Lausanne in Lausanne, Switzerland, from 11 through 17 July 2022.

[1] This is Martić's second singles career title and first of the year.

† Rankings are as of 27 June 2022 The following players received wildcard entry into the singles main draw: The following players received entry from the qualifying draw: † Rankings are as of 27 June 2022 The following pairs received wildcard entry into main draw: