The 2022 Internazionali Femminili di Palermo was a professional women's tennis tournament played on outdoor clay courts at the Country Time Club.

It was the 30th edition of the tournament and part of the 2022 WTA Tour.

It took place in Palermo, Italy, between 18 and 24 July 2022.

[1] Irina-Camelia Begu defeated Lucia Bronzetti 6–2, 6–2 The following players received wildcards into the main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: The following pair received entry into the doubles main draw using a special ranking: The following pair received entry as alternates: