The 2022 Monterrey Open (also known as the Abierto GNP Seguros for sponsorship reasons) was a women's tennis tournament played on outdoor hard courts.

It was the 14th edition of the Monterrey Open and a WTA 250 tournament on the 2022 WTA Tour.

It took place at the Club Sonoma in Monterrey, Mexico, from February 28 to March 6, 2022.

[1] During this tournament, the WTA and other international governing bodies of tennis including the ATP did not have players of Russia and Belarus compete under their country flags as a result of the Russian invasion of Ukraine.

[2] *per team The following players received wildcards into the main draw: The following player received a special exempt into the main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: