The 2022 Prague Open (branded as the 2022 Livesport Prague Open for sponsorship reasons) was a professional women's tennis tournament played on outdoor hard courts at the TK Sparta Prague.

It took place in Prague, Czech Republic from 25 to 31 July 2022.

This was the second edition of the tournament held on outdoor hard courts, as opposed to clay courts in previous editions.

[1] This was Bouzková’s first WTA Tour singles title.

The following players received wildcard entry into the singles main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: † Rankings are as of 18 July 2022.