The 2022 Engie Open de l'Isère was a professional tennis tournament played on indoor hard courts.

It was the twelfth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Grenoble, France between 7 and 13 February 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry using a protected ranking: The following players received entry from the qualifying draw: