The 2022 Estoril Open was a men's tennis tournament played on outdoor clay courts.

It was the 7th edition of the tournament and part of the ATP Tour 250 series of the 2022 ATP Tour.

It took place at the Clube de Ténis do Estoril in Cascais, Portugal, from 25 April through 1 May 2022.

[1] *per team The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following pairs received wildcards into the doubles main draw: