The 2022 Los Cabos Open (also known as the Abierto de Tenis Mifel for sponsorship reasons) was an ATP tennis tournament played on outdoor hard courts.

It was the 6th edition of the tournament, and part of the ATP Tour 250 series of the 2022 ATP Tour.

It took place in Los Cabos, Mexico from 1 through 6 August 2022.

[1] *per team The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: