The 2022 Firenze Open (also known as the 2022 UniCredit Firenze Open for sponsorship) is a professional men's tennis tournament played on indoor hard courts.

It was played at Palazzo Wanny in Florence, Italy, from 10 to 16 October 2022.

[1][2] The event was one of the six tournaments that were given single-year ATP 250 licenses in September and October 2022 due to the cancellation of tournaments in China because of the ongoing COVID-19 pandemic.

[3] Félix Auger-Aliassime defeated J. J. Wolf, 6–4, 6–4 Nicolas Mahut / Édouard Roger-Vasselin defeated Ivan Dodig / Austin Krajicek, 7–6(7–4), 6–3 † Rankings are as of 3 October 2022.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following pairs received wildcards into the doubles main draw: