The 2022 San Diego Open was a combined men's and women's tennis tournament played on outdoor hard courts.

It was held at the Barnes Tennis Center in San Diego, United States, from September 19 through September 25, 2022 for the men, and from October 10 through October 16, 2022 for the women.

[1] The event was primarily organized being held on a second consecutive year in the alternative sporting calendar due to the cancellation of tournaments in China during the 2022 season because of the ongoing COVID-19 pandemic, as well as the WTA's suspension of tournaments in China following former WTA player Peng Shuai's allegation of sexual assault against a Chinese government official.

[2][3][4] This is Świątek's eighth title of the year and eleventh of her career.

The following players received wildcards into the main draw: The following players received entry from the qualifying draw: The following pairs received wildcards into the doubles main draw: The following pair received entry as alternates: The following players received wildcards into the main draw: The following players used a protected ranking to enter the main draw: The following players received entry from the qualifying draw: The following players received entry as lucky losers: The following pair received a wildcard into the doubles main draw: