It was held from 8 to 12 November 2022 at the Allianz Cloud Arena in Milan, Italy.

Brandon Nakashima defeated Jiří Lehečka in the final, 4–3(7–5), 4–3(8–6), 4–2, to win the title.

Carlos Alcaraz was the reigning champion,[2] but withdrew from the event before competition began.

[3] The top eight players in the 2022 ATP Race to Milan will qualify.

Standings are determined by: 1. number of wins; 2. number of matches; 3. in two-players-ties, head-to-head records; 4. in three-players-ties, percentage of sets won, then percentage of games won, then head-to-head records; 5.