[5] Deidre DeJear, a small business owner and nominee for Secretary of State of Iowa in 2018, won the Democratic primary unopposed.

Incumbent Democratic attorney general Tom Miller, who had served in the position since 1995, and previously from 1979 to 1991, ran for re-election to an eighth consecutive and eleventh overall term in office.

Incumbent Democratic state treasurer Michael Fitzgerald, who had served in the position since 1983, ran for re-election to an eleventh term in office.

[12] Republican businessman Todd Halbur defeated former state representative Mary Ann Hanusa in the primary election.

[14] Polk County Soil and Water Conservation District Commissioner John Norwood ran for the Democrats.

Five Democrats filed to run: retired U.S. Navy admiral Michael Franken,[16] former U.S. Representative Abby Finkenauer,[17] Minden city councilor Glenn Hurst,[18] former Crawford County supervisor Dave Muhlbauer (withdrawn),[19] and former state representative Bob Krause (withdrawn).

Republicans won all four seats following the defeat of Democratic incumbent Cindy Axne in Iowa's 3rd congressional district, which she narrowly lost to Zach Nunn.