The 2022 Keio Challenger was a professional tennis tournament played on hard courts.

It was the 15th (men's) and 5th (women's) editions of the tournament and part of the 2022 ATP Challenger Tour and the 2022 ITF Women's World Tennis Tour.

It took place in Yokohama, Japan between 31 October and 13 November 2022.

The following players received wildcards into the singles main draw: The following players received entry into the singles main draw using protected rankings: The following players received entry from the qualifying draw: The following player received entry as a lucky loser: The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry from the qualifying draw: The following players received entry as a lucky loser: