[36] Two-term Republican incumbent Jason C. Buckel, who was re-elected in 2018 with 62.6 percent of the vote, was running for a third term unopposed.

[36] Two-term Republican incumbent Mike McKay, who was re-elected in 2018 with 82.1 percent of the vote, announced on July 21, 2021, that he would run for state Senate instead of seeking a third term.

[36] Six-term Democratic incumbent Adrienne A. Jones, who was re-elected in 2018 with 27.4 percent of the vote, was running for a seventh term, while two-term Democratic incumbents Benjamin Brooks and Jay Jalisi, who were re-elected in 2018 with 26.8 and 26.4 percent of the vote respectively, both announced that they would run for state Senate in the 10th district instead of seek a third term.

[36] First-term Democratic incumbents Emily Shetty and Jared Solomon, who were elected in 2018 with 30.4 and 28.0 percent of the vote respectively, were running for a second term.

As a result, the Montgomery County Democratic Central Committee voted on April 21, 2022, to select Aaron Kaufman to run for the seat.

The new 23rd district runs along the border of Prince George's and Anne Arundel counties, including Upper Marlboro, Bowie, and South Laurel.

[36] First-term Democratic incumbents Andrea Harrison and Jazz Lewis, who were elected in 2018 with 31.7 and 31.0 percent of the vote respectively, were both running for re-election.

Faye Martin Howell, who was appointed to the seat on November 12, 2021, after Erek Barron resigned to be sworn in as the United States Attorney for the District of Maryland, did not file to run for re-election in 2022.

[12] The new District 27A encompasses part of north Charles and south Prince George's counties, including Waldorf, Bryantown, and Danville.

The new District 27B encompasses parts of south Prince George's and north Calvert counties, including Chesapeake Beach and Baden.

[36] Three-term Republican incumbent Mark N. Fisher, who was re-elected in 2018 with 55.8 percent of the vote, was running for a fourth term.

[36] Two-term Republican incumbent Matthew Morgan, who was re-elected in 2018 with 69.0 percent of the vote, was running for a third term unopposed.

[36] Democratic incumbents Dana Jones, who was appointed to the seat on May 1, 2020, following the resignation of state delegate Alice J. Cain, and Shaneka Henson, who was appointed to the seat on May 16, 2019, following the resignation of state delegate Michael E. Busch, were both running for re-election to their first full terms.

The new 32nd district encompasses part of north Anne Arundel County, including Glen Burnie and Fort Meade.

Two-term Republican incumbent Sid Saab, who was re-elected in 2018 with 16.5 percent of the vote, announced on April 11, 2022, that he would run for state Senate instead of seeking a third term.

The new District 33C encompasses part of Anne Arundel County, including Cape Saint Claire and Severna Park.

The new District 34A encompasses south Harford County, including Edgewood, Aberdeen, and Havre de Grace.

[14] The new District 34B encompasses part of Harford County, including Bel Air, Glenwood, and Constant Friendship.

Two-term Republican incumbent Johnny Mautz announced on February 16, 2022, that he would run for state Senate instead of seeking a third term.

[36] Three-term Republican incumbent Charles J. Otto, who was re-elected in 2018 with 59.4 percent of the vote, was running for a fourth term in 2022.

[36] Two-term Republican incumbent Carl Anderton Jr., who was re-elected in 2018 with 94.3 percent of the vote, was running for a third term unopposed.

[36] First-term Republican incumbent Wayne A. Hartman, who was elected in 2018 with 95.4 percent of the vote, was running for a second term unopposed.

The new District 43A encompasses neighborhoods in north Baltimore, including Glen Oaks, Charles Village, and Northwood.

First-term Democratic incumbent Regina T. Boyce, who was elected in 2018 with 32.0 percent of the vote, was running for re-election to a second term.

[36] Democratic incumbent Roxane L. Prettyman, who was appointed to the seat on August 23, 2021, following the resignation of Keith E. Haynes, did not file to run for re-election to a full term.

Democratic incumbent Sheila Ruth, who was appointed to the seat on January 31, 2020, after Charles E. Sydnor III was appointed to the Maryland Senate, was running for re-election while two-term incumbent Pat Young announced on May 10, 2021, that he would not seek re-election to a third term, instead running for the Baltimore County Council in District 1 in 2022.

[7] The new 46th district encompasses neighborhoods in central and south Baltimore, including the Inner Harbor, Bayview, and Curtis Bay.

Two-term incumbent Brooke Lierman, who received 28.6 percent of the vote in 2018, announced on December 17, 2020, that she would run for Comptroller rather than seek a third term in 2022.

[17] Republicans J. Brian Voss and Mekkah X. Mohammed ran unopposed in the primary, but were disqualified from running in the general election.

[36] First-term Democratic incumbent Wanika B. Fisher, who was elected in 2018 with 99.1 percent of the vote, announced on June 9, 2021, that she would run for the Prince George's County Council in District 2 rather than seek a second term in 2022.