In the 2022 elections, Governor Larry Hogan was term-limited and Democrats assembled a large field of candidates to reclaim the office.

The party retained their majority in the General Assembly and successfully retook the governor's office, and re-established a government trifecta.

Republican incumbent Paul D. Corderman ran for a full term after being appointed to the seat on September 1, 2020, following the resignation of Andrew A. Serafini, who was re-elected in 2018 with 71.7% of the vote.

Two-term Republican incumbent Michael Hough, who was re-elected in 2018 with 59.1% of the vote, announced on May 17, 2021, that he would run for Frederick County executive instead of seeking a third term.

Two-term Republican incumbent Justin Ready, who was re-elected in 2018 with 71.5% of the vote, ran for a third term, unopposed.

Two-term Republican incumbent Johnny Ray Salling, who was re-elected in 2018 with 55.3% of the vote, ran for a third term.

Five-term Democratic incumbent Kathy Klausmeier, who was re-elected in 2018 with 51.1% of the vote, ran for a sixth term.

First-term Democratic incumbent Katie Fry Hester, who was elected in 2018 with 50.8% of the vote, ran for a second term.

Democratic incumbent Shelly L. Hettleman ran for a full term after being appointed to the seat on February 3, 2020, following the resignation of Robert Zirkin, who was re-elected in 2018 with 96.9% of the vote.

The Montgomery County Republican Central Committee consequently nominated Anita Cox to run against Kramer in the general election.

Seven-term Democratic incumbent Paul G. Pinsky, who was re-elected in 2018 with 92.4% of the vote, ran for an eighth term.

Democratic incumbent Ron Watson ran for a full term after being appointed to the seat on August 31, 2021, following the resignation of Douglas J. J. Peters, who was re-elected in 2018 with 98.6% of the vote.

Three-term Democratic incumbent Joanne C. Benson, who was re-elected in 2018 with 99.2% of the vote, ran for a fourth term, unopposed.

First-term Democratic incumbent Obie Patterson, who was elected in 2018 with 92.5% of the vote, announced on April 6, 2022, that he would not seek re-election to a second term.

Democratic incumbent Michael Jackson ran for a full term after being appointed to the seat on January 13, 2021, following the resignation of former president of the Maryland Senate Thomas V. Miller Jr., who was re-elected in 2018 with 66.0% of the vote.

First-term Republican incumbent Jack Bailey, who was elected in 2018 with 60.2% of the vote, ran for a second term, unopposed.

[19] Edward R. Reilly Republican Dawn Gile Democratic The new 33rd district encompasses central Anne Arundel County, including Cape St. Claire, Severna Park, Odenton, and Crofton.

[17] Bob Cassilly Republican Mary-Dulany James Democratic The new 34th district encompasses south Harford County, including Aberdeen, Edgewood, and Havre de Grace.

Two-term incumbent Robert Cassilly, who was re-elected in 2018 with 50.1% of the vote, announced on April 28, 2021, that he would run for Harford County executive instead of seeking a third term.

[18] Maryland Matters identified both the Democratic and Republican primary elections in District 34 as a "race to watch".

[19] Mary Beth Carozza Republican Mary Beth Carozza Republican The new 38th district encompasses all of Worcester and Somerset counties, and part of Wicomico County, including Ocean City, Pocomoke City, Princess Anne, and part of Salisbury.

Democratic incumbent Charles E. Sydnor III ran for a full term after being appointed to the seat on January 8, 2020, following the resignation of Shirley Nathan-Pulliam, who was re-elected in 2018 with 84.5% of the vote.

First-term Democratic incumbent Cory V. McCray, who was elected in 2018 with 98.8% of the vote, ran for a second term, unopposed.

Three-term Democratic incumbent and President of the Maryland Senate Bill Ferguson, who was re-elected in 2018 with 78.2% of the vote, ran for a fourth term.