The 2022 Mercer Tennis Classic was a professional tennis tournament played on outdoor hard courts.

It was the tenth edition of the tournament which was part of the 2022 ITF Women's World Tennis Tour.

It took place in Macon, Georgia, United States between 17 and 23 October 2022.

[1] The following players received wildcards into the singles main draw: The following player received entry into the singles main draw using a protected ranking: The following players received entry from the qualifying draw: The following players received as lucky losers: